Fig. (6).

Lesion Volume with No Tissue Perfusion for a 15 Minute Ablation with a Constant 22.5 Volt Source. Graph shows the total volume of tissue necroses calculated for a 15 minute ablation using a constant 22.5 volt source, using cell damage thresholds (D), isothermal temperatures (IT), and thermal dosing (C) with no tissue perfusion. Although the lesion growth rate calculated for 340 cumulative equivalent minutes at 43°C (C340) and for an isothermal temperature of 47°C (IT47) are very similar, they grossly overestimate the rate of lesion growth. The graph shows that the IT60 curve is a better approximation of modeled cell damage calculated using either the 63% or 100% iso-damage contours methods.