Table 4.

Lesion Volume with 100% Normal Tissue Perfusion

	Width (mm)						Depth (mm)
Source Voltage (Volts)	D=63%	D=100%	IT=42°C1	IT=47°C1	IT=60°C	C43=340 min	D=63%	D=100%	IT=42°C1	IT=47°C1	IT=60°C	C43=340 min
0	0	0	0	0	0	0	0	0	0	0	0	0
2.5	0	0	0	0	0	0	0	0	0	0	0	0
5.0	0	0	0	0	0	0	0	0	0	0	0	0
7.5	0	0	0	0	0	0	0	0	0	0	0	0
10.0	0	0	26	0	0	0	0	0	20	0	0	0
12.5	0	0	28	26	0	26	0	0	25	20	0	20
15.0	0	0	30	26	0	28	0	0	28	22	0	25
17.5	26	26	32	28	6	30	20	20	30	26	20	26
20.0	26	26	34	30	26	32	22	21	31	28	20	28
22.5	28	28	36	32	28	34	26	22	33	30	22	30

¹The 42°C and 47°C isothermal volumes were chosen specifically because they are frequently used to establish damage thresholds in hyperthermia and radiofrequency ablation, respectively.

Values represent the maximum lesion width and depth calculated over the course of the simulated ablation using various cell damage thresholds (D), isothermal temperatures (IT), and thermal dosing times (C₄₃) with 100% normal tissue perfusion(6.4 x 10^-3 m_b³/m_t³/s). The data show overestimations in lesion dimensions calculated using traditional isothermal temperatures of 42°C and 47°C. Similar overestimation of lesion dimensions are found with the thermal dosing method. The data demonstrate that lesion width and depth are relatively insensitive methods of reporting lesion growth for a multi-tyne probe geometries, since the extent of the lesion may reflect the development of several smaller lesion areas. This explains why there is virtually no transition between the absence and presence of a lesion.