Figure 2.

Effect of Ro25-6981 on LTP in cultured hippocampal slices over development. A, B, Time course of LTP in control conditions (open circles) and in the presence of 5 μm Ro25-6981 (filled circles) at DIV 6–8 (A; n = 10 for control; n = 6 for Ro25-6981; p < 0.05) and DIV 11–14 (B; n = 12 for control; n = 9 for Ro25-6981; p = 0.86) (Wilcoxon's test at 20–30 min) Insets show example averaged EPSCs taken before and 30 min after pairing for control cells (left, open circle) and cells in the presence of Ro25-6981 (right, filled circle).