Figure 7.

Effect of mutations in the C-terminal tail of NR2A on LTP. A, Histograms showing the average ratio of the NMDA–EPSC (n = 11, 9, and 8) (a) and the ratio of the half-widths (HW) (n = 11, 9, and 8) (b) in transfected and untransfected cells for NR2B–RNAi alone and NR2B–RNAi plus NR2AΔC₁₂₀₄ or NR2A–S1462A), the ratio of the AMPA–EPSC (n = 9 and 15) (c), respectively, for NR2B–RNAi plus NR2AΔC₁₂₀₄ or NR2A–S1462A. B, C, The time course of LTP in untransfected cells (open circles) and neighboring cells transfected with NR2B–RNAi plus either NR2AΔC₁₂₀₄ (n = 7; p < 0.9) (B) or NR2A–S1462A (n = 7; p < 0.05) (C) (Wilcoxon's test at 20–30 min). *p < 0.05, **p < 0.01.