Table 1.
Study [Ref] |
Country of origin |
Rando mizatio n |
Patients | Enrollme nt period |
Total patient s |
Age (mean ± SD) | Male/Female | Test for confirming infection |
Test for confirming eradication |
||
---|---|---|---|---|---|---|---|---|---|---|---|
Concomitant | Triple | Concomitant | Triple | ||||||||
*Catalano et al 2000 [20] |
Italy | RCT | PUD | 1/1998- 12/1999 |
111 | 41.2±14.2 | 45.1±12.9 | 30/26 | 29/26 | RUT & histology | RUT & histology |
*Neville et al 1999 [22] |
UK | RCT | PUD, NUD & others |
NR | 112 | 50.5±15 | 56±13 | 21/35 | 37/19 | Culture, RUT, UBT & histology |
UBT |
*Nagahara et al 2000 [21] |
Japan | RCT | PUD & NUD | 8/1998 – 5/1999 |
105 | 53.8±13.9 | 52.5±11.9 | 40/15 | 34/16 | RUT, UBT, histology & HpSA |
HpSA |
*Treiber et al 1998 [11] |
Germany | RCT | PUD & others | NR | 88 | 53.5±15.7 | 55±17 | 32/14 | 28/14 | RUT & UBT | RUT, UBT & histology |
*Nagahara et al 2001 [23] |
Japan | RCT | PUD & NUD | 7/1999- 5/2000 |
160 | 50±12.1 | 49.1±12.3 | 60/20 | 58/22 | RUT, UBT & histology |
UBT |
Okada et al 1999 [24] |
Japan | Non- RCT |
PUD & other | 6/1997- 5/1998 |
169 | 47±14 | _ | 121/48 | None | Culture, RUT & histology |
Culture, RUT & histology |
Calvet et al 2000 [25] |
Spain | Non- RCT |
PUD | 11/1996- 6/1997 |
56 | 55.2±16 | _ | 40/16 | None | UBT & histology | UBT & histology |
‡Treiber et al 2002 L5 [26] |
Germany | RCT | PUD, NUD & others |
4/1997- 3/1999 |
83 | 54.6±14 | _ | 50/33 | None | Culture, RUT, UBT, histology & serology |
UBT |
‡Treiber et al 2002 L3 [26] |
Germany | RCT | PUD, NUD & others |
4/1997- 3/1999 |
80 | 56.5±14 | _ | 47/33 | None | Culture, RUT, UBT, histology & serology |
UBT |
Okada et al 1998 [12] |
Japan | Non- RCT |
PUD, NUD & others |
NR | 90 | 46.2±13.1 | 70/20 | None | Culture, RUT & histology | Culture, RUT, & histology |
= RCT comparing PPI-concomitant quadruple therapy vs. triple therapy;
=RCT comparing PPI-concomitant quadruple therapy vs. non triple therapy, NUD= Non Ulcer Dyspepsia, PUD= Peptic Ulcer Disease, RUT= Rapid Urease test, UBT= Urea Breath Test, NR= Not Recorded L5 Lansoprazole concomitant quadruple therapy for 5 days , L3= Lansoprazole concomitant quadruple therapy for 3 days.