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Weight gain in WT and hl−/− female mice on chow (A and C) and HF (B and C) diets. WT mice (n = 6–7 per group) and hl−/− mice (n = 5–6 per group) were fed either a chow (4.5% fat) diet or a HF (21% fat) diet for 12 wk. Cumulative weight gain is plotted in A and B. C, The weight gain is shown as the difference between the body weights on the first and last days of the 12-wk study; P < 0.0002 for contribution of genotype by two-way ANOVA on d 83 of diet. hl−/−, HL-deficient mice.
