Adipose tissue characteristics in WT and hl−/− mice. A and B, Photomicrographs of H&E stained gonadal adipose tissue from HF fed mice. Size bar, 100 μm. Note reduced cell size, increased number of nuclei in hl−/− mice. E, Quantitation of adipocyte size, P < 0.01 vs. WT mice. ATMs in WT and hl−/− mice. C and D, Photomicrographs of Mac2 stained gonadal adipose tissue from HF fed mice. Size bar, 100 μm. Note increased number of macrophages in WT mice. F, Quantitation of macrophages, P = 0.005 vs. WT mice.