Cumulative FI in WT and hl−/− female mice on chow and HF diets. Daily food intake was measured for 12 wk during (A) chow diet (WT, n = 4; hl−/−, n = 6) and (B) HF diet (WT, n = 7; hl−/−, n = 5). Results are reported as group means ± se for each day and is expressed as kilocalories. Two-way ANOVA on d 83 of each diet indicates a major contribution of genotype to the food intake phenotype; *, P < 0.0001. C, Average daily food intake in WT and hl−/− female mice on chow and HF diets. Two-way ANOVA demonstrates a significant contribution of genotype to the daily FI phenotype; *, P < 0.0001. All measurements were obtained between 0830 and 1030 h. The FI is expressed as kilocalories consumed per day.