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LEFTY inhibits decidual reprogramming. Endometrial stromal cells under the influence of diverse deciduogenic signals such as estrogen/P4 combination or cAMP decidualize and release LEFTY, IGFBP1, and PRL. LEFTY acts as an inhibitor of decidualization and restrains expression of ETS1 and FOXO1 that, in turn, regulate the expression IGFBP1 and PRL.
