TCORE (A) and HLI (B) of OVX and OVX+E rats at TAMBIENT from 13 to 34 C. Values represent mean ± sem (n = 11–12 rats/group). A, At most TAMBIENT, estradiol-17β had no effect on average TCORE. However, at TAMBIENT above 32.5 C, the TCORE of OVX rats was significantly higher than OVX+E rats. B, The overall average HLI was significantly decreased by estradiol treatment (two-way repeated ANOVA). *, Specific TAMBIENT at which OVX and OVX+E was significantly different, based on post hoc tests (P < 0.05).