We measured fibrin fiber diameters in four separate experiments (2–5 images acquired per clot and ~100 fibers measured per clot). Because of variability in the control samples (see Results), we determined the percent difference from the appropriate control for each fiber measured. The average difference ± standard error of the mean for each %RBCs is shown. P-values were obtained for comparison of these difference values with those from the 0% RBC control sample using an independent Student’s t-test.