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. 1980 Nov;18(5):691–695. doi: 10.1128/aac.18.5.691

Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation.

S Omura, Y Tanaka, C Kitao, H Tanaka, Y Iwai
PMCID: PMC284077  PMID: 7447425

Abstract

Addition of magnesium phosphate [Mg3(PO4)2 x 8H2O] to a complex medium or to an ammonium ion-containing, chemically defined medium stimulated leucomycin production by Streptomyces kitasatoensis. Ammonium ions in high concentrations inhibited leucomycin production, but their limitation by magnesium phosphate led to the high production of the antibiotic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aharonowitz Y., Demain A. L. Nitrogen nutrition and regulation of cephalosporin production in Streptomyces clavuligerus. Can J Microbiol. 1979 Jan;25(1):61–67. doi: 10.1139/m79-010. [DOI] [PubMed] [Google Scholar]
  2. Drew S. W., Demain A. L. Effect of primary metabolites on secondary metabolism. Annu Rev Microbiol. 1977;31:343–356. doi: 10.1146/annurev.mi.31.100177.002015. [DOI] [PubMed] [Google Scholar]
  3. Dulaney E. L. Observations on Streptomyces griseus: II. Nitrogen Sources for Growth and Streptomycin Production. J Bacteriol. 1948 Sep;56(3):305–313. [PMC free article] [PubMed] [Google Scholar]
  4. Omura S., Nakagawa A. Chemical and biological studies on 16-membered macrolide antibiotics. J Antibiot (Tokyo) 1975 Jun;28(6):401–433. doi: 10.7164/antibiotics.28.401. [DOI] [PubMed] [Google Scholar]
  5. Omura S., Nakagawa A., Takeshima H., Atusmi K., Miyazawa J., Piriou F., Lukacs G. Letter: Biosynthetic studies using 13C enriched precursors on the 16-membered macrolide antibiotic leucomycin A3. J Am Chem Soc. 1975 Oct 29;97(22):6600–6602. doi: 10.1021/ja00855a065. [DOI] [PubMed] [Google Scholar]
  6. Penzikova G. A., Sepanova N. E., Levitov M. M. Izuchenie osobennostei biosinteza fuzidina shtammom Fusidium coccineum 257 A. Antibiotiki. 1977 Jan;22(1):29–32. [PubMed] [Google Scholar]
  7. SMITH C. G. Effect of aeration on the novobiocin fermentation. Appl Microbiol. 1960 Jan;8:42–46. doi: 10.1128/am.8.1.42-46.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Surikova E. I., Novikova L. M., Gerasimova T. M. Izuchenie zakonomernostei rosta Act. antibioticus i biosintez oleandomitsina. Antibiotiki. 1976 Mar;21(3):195–200. [PubMed] [Google Scholar]
  9. Ward A. C., Packter N. M. Relationship between fatty-acid and phenol synthesis in Aspergillus fumigatus. Eur J Biochem. 1974 Jul 15;46(2):323–333. doi: 10.1111/j.1432-1033.1974.tb03624.x. [DOI] [PubMed] [Google Scholar]

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