Table 3.
Gender-related distribution of the CTLA-4 C-819 T SNP polymorphism in the Egyptian population
| Genotype | Female patient age groups | Female Controls | Male patient age group | Male Controls | ||||
|---|---|---|---|---|---|---|---|---|
| 0-5 | 6-14 | 0-14 | 25-39 | 0-5 | 6-14 | 0-14 | 25-39 | |
| (N=99) | (N=99) | (N=198) | (N=198) | (N=99) | (N=99) | (N=198) | (n=198) | |
| CC | 38 (38.38%) | 41 (41.41%) | 79 (39.9%) | 104 (52.52%) | 50 (50.50%) | 51 (51.51%) | 101 (51.01%) | 110 (55.56%) |
| CT | 49 (49.49%) | 46 (46.46%) | 95 (48%) | 84 (42.42) | 41 (41.41%) | 42 (42.42%) | 83 (41.92%) | 80 (40.40%) |
| TT | 12 (12.13%) | 12 (12.13%) | 24 (12.1%) | 10 (5.06%) | 8 (8.09%) | 6 (6.07%) | 14 (6.57%) | 8 (4.04%) |
| Allele C | 125 (63.13%) | 128 (64.65%) | 253 (63.9%) | 292 (73.74%) | 141 (71.21%) | 144 (72.73%) | 285 (71.97%) | 300 (75.76%) |
| Allele T | 73 (36.87%) | 70 (35.35%) | 143 (36.1%) | 104 (26.26%) | 57 (28.79%) | 54 (27.27%) | 111 (28.03%) | 96 (24.24%) |
| (0-5) Females | (6-14) Females | (0-14) Females | (0-5) Males | (6-14) Males | (0-14) Males | |||
| Statistical Analysisa parameter | ||||||||
| (N=99) | (N=99) | (N=198) | (N=99) | (N=99) | (N=198) | |||
| Genotype | χ2 | 7.952 | 6.3697 | 9.8560 | 2.3290 | 1.8358 | 2.0755 | |
| P value | 0.0186 | 0.041385 | 0.0071 | 0.3120 | 0.6587 | 0.3542 | ||
| Allele | χ2 | 7.0982 | 4.190 | 8.9487 | 1.4262 | 0.6422 | 1.4716 | |
| P value | 0.007716 | 0.021734 | 0.00277 | 0.2323 | 0.4229 | 0.2250 | ||
| Odds ratio | 0.610184 | 0.651108 | 0.63211 | 0.788979 | 0.849592 | 0.822912 | ||
χ2 and P values were calculated by Chi-square tests
a
Compared to controls
b
Continuity corrected