Table 4.
Distribution of the CTLA-4 A+49G SNP polymorphism gene in the Egyptian population
| Patient age groups | Controls | |||
|---|---|---|---|---|
| Genotype | 0-5 age group, N=198 | 6-14 age group, N=198 | 0-14 age group, N=396 | 25-39 age group, N=396 |
| AA | 79 (39.90%) | 87 (43.94%) | 166 (41.92%) | 215 (54.29%) |
| AG | 90 (45.45%) | 85 (42.93%) | 175 (44.20%) | 150 (37.88%) |
| GG | 29 (14.65%) | 26 (13.13%) | 55 (13.88%) | 31 (7.83%) |
| Allele A | 248 (0.626) | 259 (0.654) | 507 (0.640) | 580 (0.732) |
| Allele G | 148 (0.347) | 137 (0.346) | 285 (0.360) | 212 (0.268) |
| Statistical Analysisa Parameter | Patient age group (0-5) | Patient age groups (6-14) | Patient age groups (0-14) | |
| Genotype | χ2,a | 13.4755 | 7.5026 | 14.9226 |
| P value | 0.001185 | 0.023487 | 0.000575 | |
| Allele | χ2,b | 14.0609 | 7.7980 | 15.6248 |
| P value | 0.000177 | 0.00523 | 0.0000772 | |
| Odds Ratio | 0.612656 | 0.690713 | 0.65118 | |
χ2 and P values were calculated by Chi-square test on stratified 2 × 2 table
a
Compared to controls
b
Continuity corrected