Table 5.
Gender-related Distribution of the CTLA-4 A+49G SNP Polymorphism in the Egyptian population
| Female Patient age groups | Female Controls | Male Patient age group | Male Controls | |||||
|---|---|---|---|---|---|---|---|---|
| 0-5 | 6-14 | 0-14 | 25-39 | 0-5 | 6-14 | 0-14 | 25-39 | |
| Geno type | (N=99) | (N=99) | (N=198) | (N=198) | (N=99) | (N=99) | (N=198) | (n=198) |
| AA | 34 (34.34%) | 39 (41.41%) | 73 (36.87%) | 109(55.05%) | 45 (45.45%) | 48 (48.48%) | 93 (46.97%) | 106 (53.54%) |
| AG | 47 (47.47%) | 45 (45.45%) | 92 (46.46%) | 73 (36.87%) | 43 (43.43%) | 40 (40.40%) | 83 (41.92%) | 77 (38.89%) |
| GG | 12 (18.19%) | 15 (15.16%) | 34 (16.67%) | 16 (8.08%) | 11 (11.12%) | 11 (11.22%) | 22 (11.11%) | 15 (7.57%) |
| Allele A | 115 (0.58) | 123 (0.621) | 238 (0.598) | 291 (0.735) | 133 (0.672) | 136 (0.687) | 269 (0.679) | 289 (0.730) |
| Allele G | 83 (0.42) | 75 (0.379) | 160 (0.402) | 105 (0.265) | 65 (0.328) | 62 (0.313) | 127 (0.321) | 107 (0.270) |
| 0-5 Females | 6-14 Females | 0-14 Females | 0-5 Males | 6-14 Males | 0-14 Males | |||
| Statistical Analysisa parameter | ||||||||
| (N=99) | (N=99) | (N=198) | (N=99) | (N=99) | (N=198) | |||
| Genotype | χ2 | 13.5975 | 7.6325 | 15.7863 | 2.1275 | 1.3054 | 2.3986 | |
| P value | 0.00115 | 0.02201 | 0.000373 | 0.345161 | 0.520627 | 0.30141 | ||
| Allele | χ2 | 14.4788 | 8.0707 | 16.7202 | 2.1646 | 1.1950 | 2.4262 | |
| P value | 0.000142 | 0.004499 | 0.0000433 | 0.141224 | 0.274318 | 0.119318 | ||
| Odds ratio | 0.501305 | 0.592286 | 0.538884 | 0.756113 | 0.809852 | 0.78556 | ||
χ2 and P values were calculated by Chi-square tests
a
Compared to controls
b
Continuity corrected