Figure 5.

Effects of rAAV-leptin on glucose metabolism and insulin secretion. Untreated C57 mice or ob/ob mice treated with rAAV-leptin or saline were fasted for 18 hr and bled for determination of fasting glucose (A) and insulin (B), 6 weeks postinjection. The values presented here are the mean ± SEM of five mice. (C) Glucose tolerance was determined in saline (▵), rAAV-leptin-treated (○), or C57 (∗) mice by measuring blood glucose levels at indicated times after i.p. injection of glucose. Values are the mean ± SEM of three mice in each group. Test were performed on fasted mice, 8 weeks postinjection.