Table 2. Association Results in Type 1 Diabetes for CCR5 and CCR2 Variants.
| Maximum 8,064 Cases and 9,339 Controls |
2,519 Parent-child Trios |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Allele/ genotype |
frequency n (%) cases |
frequency n (%) controls |
OR (95% CI) |
P-values 1-df 2-df |
frequency n (%) cases |
frequency n (%) parents |
RR (95% CI) |
P-values 1-df 2-df |
Combined P 1-df 2-df |
| 3p21/CCR5 | del | 814 (10.33) | 1,155 (11.90) | 0.85 (0.80-0.92) | 5.72 × 10−6 | 309 (10.06) | 503 (10.67) | 0.90 (0.75-1.09) | 0.116 | 1.49 × 10−6 |
| rs333 | ins/ins | 6,320 (80.23) | 7,554 (77.83) | 1.00 (reference) | 2,496 (80.65) | 1,887 (80.13) | 1.00 (reference) | |||
| del32 | ins/del | 1,487 (18.88) | 1,994 (20.54) | 0.89 (0.82-0.96) | 572 (18.48) | 433 (18.39) | 0.97 (0.86-1.10) | |||
| del/del | 70 (0.89) | 158 (1.63) | 0.54 (0.40-0.72) | 1.88 × 10−6 | 27 (0.87) | 35 (1.49) | 0.53 (0.34-0.82) | 9.10 × 10−3 | 1.81 × 10−8 | |
| 3p21/CCR2 | A | 582 (7.50) | 564 (7.68) | 0.97 (0.89-1.06) | 0.506 | N/A | ||||
| rs1799864 | G/G | 6,641 (85.57) | 6,262 (85.32) | 1.00 (reference) | ||||||
| Ile64Val | A/G | 1,074 (13.86) | 1,027 (13.99) | 0.99 (0.90-1.08) | 0.556 | |||||
| A/A | 44 (0.57) | 50 (0.68) | 0.80 (0.53-1.21) | |||||||
OR = odds ratio, 95% CI = 95% confidence intervals, RR = relative risk, N/A = not attempted
A 2-df test is reported as there was a significant difference between genotypic effects model and the multiplicative allelic effects model.