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. 2009 Dec 11;95(2):820–828. doi: 10.1210/jc.2009-1888

Figure 3.

Figure 3

TSH enhancement of expression of NIS, TSHR, and TPO genes induced by various inhibitors, individually or in different combinations, in thyroid cancer cells. Various thyroid cancer cells were treated with specific inhibitors (RDEA119, CCI779, perifosine, and SAHA) as described in Fig. 1 and in Materials and Methods, individually or in different combinations, supplemented with or without 20 mU/ml TSH. Data are presented as the mean ± sd of values from three assays. R, RDEA119; C, CCI779 (temsirolimus); P, perifosine; S, SAHA. *, P < 0.05; **, P < 0.01 for comparison with control.