Table 2.
Change in body composition and cardiovascular risk marker variables with treatment
| Placebo
|
GH
|
P value comparing baseline between groups | P value comparing change at 6 months between groups | |||
|---|---|---|---|---|---|---|
| Baseline | Change | Baseline | Change | |||
| Total body fat (kg) | 32.3 ± 12.0 | 0.7 ± 2.2 | 29.9 ± 9.2 | −1.6 ± 3.2 | 0.54 | 0.04 |
| Total abdominal fat (mm2) | 46949 ± 16674 | 1164 ± 4319 | 47654 ± 12725 | −4434 ± 7684 | 0.91 | 0.04 |
| Subcutaneous adipose tissue (mm2) | 30778 ± 13304 | 1288 ± 4257 | 33447 ± 11047 | −2430 ± 5247 | 0.57 | 0.06 |
| Visceral adipose tissue (mm2) | 19006 ± 9922 | 540 ± 2401 | 14207 ± 6730 | −2004 ± 3515 | 0.14 | 0.03 |
| Total fat-free mass (kg) | 59.9 ± 17.1 | −0.1 ± 1.9 | 58.7 ± 13.4 | 1.5 ± 1.4 | 0.84 | 0.02 |
| Total body water (kg) | 47.5 ± 16.5 | −0.8 ± 4.4 | 43.85 ± 9.7 | 1.4 ± 2.1 | 0.49 | 0.13 |
| Resting energy expenditure (kcal) | 1665.6 ± 351.9 | −24.9 ± 229.5 | 1513.1 ± 256.9 | 146.9 ± 163.5 | 0.21 | 0.04 |
| Mean arterial pressure (mm Hg) | 91.1 ± 8.0 | −2.2 ± 7.8 | 89.1 ± 7.7 | −1.4 ± 7.9 | 0.50 | 0.80 |
| Total cholesterol (mg/dl) | 196 ± 28 | −9 ± 22 | 189 ± 44 | −8 ± 18 | 0.61 | 0.93 |
| HDL (mg/dl) | 46 ± 14 | −8 ± 11 | 53 ± 13 | −8 ± 9 | 0.15 | 0.91 |
| LDL (mg/dl) | 125 ± 27 | −4 ± 20 | 119 ± 37 | −3 ± 18 | 0.62 | 0.90 |
| Triglycerides (mg/dl) | 127 ± 39 | 17 ± 53 | 86 ± 32 | 17 ± 29 | 0.004 | 0.98 |
| hsCRP (mg/liter) | 3.23 ± 2.42 | 1.64 ± 3.36 | 2.93 ± 3.32 | −0.36 ± 1.52 | 0.78 | 0.05 |
| Mean IMT (mm) | 0.65 ± 0.12 | −0.008 ± 0.03 | 0.66 ± 0.16 | 0.008 ± 0.05 | 0.81 | 0.32 |
| Fibrinogen (mg/dl) | 306 ± 60 | 13 ± 74 | 339 ± 68 | −19 ± 62 | 0.91 | 0.24 |
| Fasting glucose (mg/dl) | 87 ± 11 | 1 ± 10 | 83 ± 7 | 2 ± 10 | 0.26 | 0.91 |
| Fasting insulin (μIU/ml) | 9.70 ± 6.54 | 2.08 ± 2.57 | 10.28 ± 4.67 | 3.47 ± 10.17 | 0.79 | 0.62 |
| HOMA-IR | 2.16 ± 1.61 | 0.49 ± 0.63 | 2.23 ± 0.97 | 0.89 ± 2.68 | 0.89 | 0.59 |
| Hemoglobin A1c (%) | 5.79 ± 0.50 | 0.03 ± 0.35 | 5.49 ± 0.35 | 0.19 ± 0.36 | 0.07 | 0.23 |
Data are presented mean ± sd. Mean arterial pressure = diastolic blood pressure + 1/3 (systolic blood pressure − diastolic blood pressure). Significant P values are bolded.