Table 2.
Genotype frequencies within group, race and family relationship (top panel), case-control analyses within Caucasian and Hispanic subjects (middle panel) and case-control power analyses (bottom panel)
| Genotype frequency n (%) | ||||
|---|---|---|---|---|
| AA | AG | GG | Total | |
| Patients | ||||
| White | 58 (32.6) | 73 (41.0) | 47 (26.4) | 178 |
| Hispanic | 45 (31.7) | 52 (36.6) | 45 (31.7) | 142 |
| Other | 24 (47.1) | 19 (37.3) | 8 (15.7) | 51 |
|
|
||||
| Total | 127 (34.2) | 144 (38.8) | 100 (27.0) | 371 |
| Controls | ||||
| White | 32 (31.4) | 54 (52.9) | 16 (15.7) | 102 |
| Hispanic | 20 (31.3) | 31 (48.4) | 13 (20.3) | 64 |
| Other | 13 (68.4) | 4 (21.1) | 2 (10.5) | 19 |
|
|
||||
| Total | 65 (35.1) | 89 (48.1) | 31 (16.8) | 185 |
| Patient Siblings | ||||
| White | 31 (25.7) | 59 (50.9) | 26 (22.4) | 116 |
| Hispanic | 23 (22.5) | 42 (41.2) | 37 (36.3) | 102 |
| Other | 10 (37.0) | 10 (37.0) | 7 (25.9) | 27 |
|
|
||||
| Total | 64 (26.1) | 111 (45.3) | 70 (28.6) | 245 |
| Control Siblings | ||||
| White | 26 (26.5) | 48 (49.0) | 24 (24.5) | 98 |
| Hispanic | 12 (25.0) | 22(45.8) | 14 (29.2) | 48 |
| Other | 8 (47.1) | 7 (41.2) | 2 (11.8) | 17 |
|
|
||||
| Total | 46 (28.2) | 77 (47.2) | 40 (24.5) | 163 |
| Patient Fathers | ||||
| White | 19 (26.8) | 31 (43.7) | 21 (29.6) | 71 |
| Hispanic | 9 (27.3) | 14 (42.4) | 10 (30.3) | 33 |
| Other | 2 (22.2) | 7(77.8) | 0 | 9 |
|
|
||||
| Total | 30 (26.5) | 52 (46.0) | 31 (27.4) | 113 |
| Control Fathers | ||||
| White | 19 (29.7) | 30(46.9) | 15 (23.4) | 64 |
| Hispanic | 7 (20.6) | 19 (55.9) | 8 (23.5) | 34 |
| Other | 3 (42.9) | 3 (42.9) | 1 (14.3) | 7 |
|
|
||||
| Total | 29 (27.6) | 52 (49.5) | 24 (22.9) | 105 |
| Patient Mothers | ||||
| White | 41 (31.1) | 55 (41.7) | 36 (27.3) | 132 |
| Hispanic | 21 (24.1) | 39 (44.8) | 27 (31.0) | 87 |
| Other | 11 (47.8) | 6 (26.1) | 6 (26.1) | 23 |
|
|
||||
| Total | 73 (30.2) | 100 (41.3) | 69 (28.5) | 242 |
| Control Mothers | ||||
| White | 32 (33.3) | 45 (46.9) | 19 (19.8) | 96 |
| Hispanic | 11 (23.9) | 22 (47.8) | 13 (28.3) | 46 |
| Other | 10 (62.5) | 5 (31.3) | 1 (6.3) | 16 |
|
|
||||
| Total | 53 (33.5) | 72 (45.6) | 33 (20.9) | 158 |
| Case-Control Analyses: | ||||
|---|---|---|---|---|
| Within Caucasian and Hispanic subjects: | ||||
| Patients with CD | 92 (31.9) | 114 (39.6) | 82 (28.5) | 288 |
| Controls without CD χ2=7.93; p=0.02 |
44 (31.4) | 72 (51.4) | 24 (17.1) | 140 |
| Patients with AUD | 81 (34.3) | 89 (37.7) | 66 (28.0) | 236 |
| Controls without AUD χ2=5.3; p=0.07 |
47 (34.3) | 65 (47.4) | 25 (18.2) | 137 |
| Patients with AD | 36 (36.4) | 39 (39.4) | 24 (24.2) | 99 |
| Controls without AD χ2=1.91; p=0.39 |
47 (34.3) | 65 (47.4) | 25 (18.2) | 137 |
| Case-Control Power Analyses: | ||||
|---|---|---|---|---|
| # of patients | # of controls | Odds Ratio | ||
| 1.02 | 2.00 | 3.90 | ||
| 288 | 140 | 5% | 82% | 99% |
| 236 | 137 | 5% | 75% | 99% |
CD = at least 3 DSM-III-R conduct disorder criteria (lifetime); AD = DSM-IV-defined alcohol dependence (lifetime); AUD = DSM-IV-defined alcohol use disorder (lifetime); note that multiple sibs are present for some families. Power calculations assume: 1) population prevalence of disease = 0.1; (2) α = 0.05; an A-allele frequency of 0.53;(4) disease locus = marker locus; and (5) a dominant model.