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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Bioorg Med Chem. 2010 Jan 25;18(5):1899–1909. doi: 10.1016/j.bmc.2010.01.037

Scheme 3a.

Scheme 3a

aReagents and conditions: (a) CH3CH=N(CH3)2, CH3COOH, toluene, 4 days, 5 °C, 38%; (b) NaCH2CH3CO2CH3, Et3N, toluene, Ar, 1 h, rt, then 9 h at 103–105 °C, 97%; (c) H2, Pd-C 10%, CF3COOH, 21 h, rt, 93%.