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. Author manuscript; available in PMC: 2010 Mar 17.
Published in final edited form as: Cancer Res. 2007 May 15;67(10):4759–4766. doi: 10.1158/0008-5472.CAN-06-4246

Figure 4.

Figure 4

Level of Rap1 activity affects invasiveness and tumorigenic potential of T4-2 cells. A, invasiveness of T4-vector, T4-DA-Rap1, and T4-DN-Rap1 cells was examined using Matrigel-coated transwell filters. Quantification at 48 h after plating. B, the transfectants were s.c. injected into nude mice to examine tumorigenic potential. Tumor size measured at 8 wks after injection and mice bearing tumors larger than 10 mm3 were scored. C, histology of tumors derived from T4-vector and T4-DA-Rap1 cells.