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. Author manuscript; available in PMC: 2010 Mar 17.
Published in final edited form as: J Immunol. 2006 Jan 1;176(1):329–334. doi: 10.4049/jimmunol.176.1.329

FIGURE 3.

FIGURE 3

ABM Tg TRegs exhibit powerful suppressive properties in both heart and skin allograft models. A, Thymectomized ABM mice fail to spontaneously accept bm12 heart allografts in the absence of CD4+CD25+ TRegs (p < 0.0117). B, ABM Tg CD4+CD25− T cells (105) adoptively transferred into syngeneic nude C57BL/6 hosts rapidly induce rejection of bm12 skin allografts. In contrast, the cotransfer of 105 ABM Tg, but not wild-type, TRegs precludes TEff from rejecting the allografts (p < 0.0198). To prevent 105 ABM Tg CD4+CD25− T cells from rejecting bm12 skin allografts, 3 × 105 wild-type C57BL/6 TRegs have to be cotransferred into nude recipients (p < 0.0025).