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. Author manuscript; available in PMC: 2010 Mar 17.
Published in final edited form as: Am J Physiol Regul Integr Comp Physiol. 2007 Sep 26;293(6):R2295–R2305. doi: 10.1152/ajpregu.00365.2007

Fig. 3.

Fig. 3

Baroreflex-independent GABAergic inhibition of RVLM is potentiated in pregnant (P) rats. In SAD rats, bilateral RVLM GABAA receptor blockade (Bic1, 4 mM, 100 nl) increased MAP, RSNA, and HR in both NP and P groups. Pressor and sympathoexcitatory responses were potentiated in P compared with NP rats (main effect of pregnancy). In contrast, the increase in HR following Bic1 was less in P rats. Bilateral blockade of AT1X in the RVLM with L-158,809 (10 mM, 100 nl) attenuated pressor and sympathoexcitatory responses to bilateral Bic (Bic2). However, increases in MAP and RSNA due to blockade of GABAA receptors in the RVLM remained potentiated in P compared with NP rats. AT1X attenuated tachycardic responses in NP rats only. Values are means ± SE. *P different from NP; †main effect of AT1X; ‡Bic1 different from Bic2; P ≤ 0.05.