Table 2.
Distribution of genotype of HO-1 gene promoter by risk factor status in stroke patients and their controls
| Stroke patients (n = 183) | Non-Stroke patients (n = 164) | |||||
|---|---|---|---|---|---|---|
| Variables | Groups | S | L | S | L | P |
| All subjects | 45 (24.6) | 138 (75.4) | 50 (30.5) | 114 (69.5) | 0.4262 | |
| Hypertension& | Yes | 37 (24.5) | 114 (35.5) | 26 (28.9) | 64 (71.1) | 0.4535 |
| No | 8 (25.0) | 24 (75.0) | 24 (32.4) | 50 (67.6) | 0.4441 | |
| Diabetes * | Yes | 10 (15.6) | 54 (84.4) | 4 (21.1) | 15 (79.0) | 0.8531 |
| None | 35 (29.4) | 84 (70.6) | 46 (31.7) | 99 (68.3) | 0.8824 | |
| TC | ≧240 mg/dL+ | 9 (34.6) | 17 (65.4) | 6 (18.8) | 26 (81.3) | 0.2310 |
| Otherwise | 36 (22.9) | 121 (77.1) | 44 (33.3) | 88 (66.7) | 0.0490 * | |
| Triglyceride | ≧200 mg/dL+ | 11 (25.0) | 33 (75.0) | 13 (34.2) | 25 (65.8) | 0.4664 |
| Otherwise | 34 (24.5) | 105 (75.5) | 37 (29.4) | 89 (70.6) | 0.3680 | |
| LDL-C | ≧130 mg/dL+ | 15 (28.9) | 37 (71.2) | 14 (21.2) | 52 (78.8) | 0.3389 |
| Otherwise | 30 (22.9) | 101 (77.1) | 36 (36.7) | 62 (63.3) | 0.0270 * | |
| HDL-C | <40/50 mg/dL in male/female | 31 (23.7) | 100 (76.3) | 29 (42.7) | 39 (57.4) | 0.0056 ** |
| Otherwise | 14 (26.9) | 38 (73.1) | 21 (21.9) | 75 (78.1) | 0.4902 | |
| TC/HDL-C ratio | ≧5+ | 14 (21.2) | 52 (78.8) | 21 (36.2) | 37 (63.8) | 0.0747 |
| Otherwise | 31 (26.5) | 86 (73.5) | 29 (27.4) | 77 (72.6) | 0.8758 | |
| smoker | Current + past | 17 (23.3) | 56 (76.7) | 12 (25.5) | 35 (74.5) | 0.8288 |
| Otherwise | 28 (25.5) | 82 (74.6) | 38 (32.5) | 79 (67.5) | 0.3060 | |
| BMI | ≧27 | 6 (26.1) | 17 (73.9) | 11 (27.5) | 29 (72.5) | 0.9032 |
| otherwise | 38 (24.4) | 121 (75.6) | 39 (31.4) | 85 (68.6) | 0.1851 | |
| Plaque score | ≧3 | 19 (22.8) | 64 (77.1) | 10 (23.3) | 33 (76.7) | 0.9633 |
| <3 | 26 (26.0) | 74 (74.0) | 40 (33.1) | 81 (66.9) | 0.3018 | |
N(%). * fasting blood glucose 126 mg/dL or on DM medication. &SBP 140 mmHg or DBP 90 mmHg or on anti-hypertension medication. + included those patients with related medication. TC: total cholesterol. HDL-C: high-density lipoprotein cholesterol; BMI: body mass index. P: the p value from chi-square test comparing genotype S and genotype L between stroke and non-stroke patients in each CVD characteristic subgroup. S and L genotypes: averaged (GT)n repeats 26 and >26, respectively. *: p < 0.05; **: p < 0.01; ***: p < 0.001