Table 2.
Univariate analyses of factors associated with OS and LMFS.
| Variable | OS (n = 98) | LMFS (n = 98) | ||
|---|---|---|---|---|
| HR, (95% CI) | P value | HR, (95% CI) | P value | |
| Gender (female vs. male) | 1.157 (0.562-2.381) | 0.693 | 0.416 (0.114-1.510) | 0.182 |
| Age (< 60 y vs. ≥ 60 y) | 0.732 (0.352-1.519) | 0.402 | 0.704 (0.230-2.153) | 0.538 |
| Invasive depth (T4 vs. T3) | 1.023 (0.392-2.674) | 0.962 | 0.902 (0.200-4.068) | 0.893 |
| Sites of primary tumors (right vs. left) | 2.271 (1.093-4.717) | 0.028* | 0.815 (0.267-2.491) | 0.720 |
| Grade (G3 vs. G2 vs. G1) | 1.519 (0.715-3.224) | 0.277 | 1.036 (0.324-3.311) | 0.953 |
| Pathologic classification (mucoid + signet ring vs. papillary + tubular) | 2.415 (1.129-5.168) | 0.023* | 1.148 (0.316-4.171) | 0.834 |
| Growth pattern (infiltrating vs. pushing) | 0.817 (0.389-1.718) | 0.595 | 2.709 (0.600-12.223) | 0.195 |
| CD68TFHotspot (4 vs. 3 vs. 2 vs.1) | 0.568 (0.393-0.822) | 0.003* | 0.594 (0.344-1.025) | 0.061 |
| CD68TFHotspot group (high vs. low) | 0.288 (0.139-0.600) | 0.001* | 0.324 (0.106-0.991) | 0.048* |
| Hepatic metastasis (yes vs. no) | 5.852 (2.737-12.511) | 0.000** | NA | NA |
Univariate analysis, Cox proportional hazards regression model. Abbreviations: HR, hazard ratio; CI, confidence interval; NA, not assessment. *: p < 0.05; **: p < 0.001.