Table 3.

Follow-up of High-Density Genomewide Association Findings (Except for APOE-Related Findings) Among Informative Families^a

		NIMH		NIA		NCRAD		CAG		Combined
Gene or Locus (SNP), Trait	Model	P Value	No. of Families	P Value	No. of Families	P Value	No. of Families	P Value	No. of Families	P Valueb	No. of Families
GAB2 (rs7101429), affection
All	Additive	.005	144	.26	111	.02	93	.21	51	.002	399
APOE ε4 positive	Additive	.008	111	.19	92	.04	82	.18	33	.003	318
APOE ε4 negative	Additive	.17	33	.74c	18	.20	11	.44	18	.34	80
GOLM1 (rs7019241), affection	Dominant	.09	86	.96c	73	.37	74	.16	28	.24	261
GWA_15q21 (rs10519262), age at onsetd	Recessive	.60c	175	.29	156	.20	132	.69c	78	.49	541
GWA_9p24 (rs9886784), affection	Recessive	.72c	156	.29	131	.75c	117	.05	69	.30	473

Abbreviations: CAG, Consortium on Alzheimer’s Genetics¹¹; NCRAD, National Cell Repository for Alzheimer’s Disease (http://www.ncrad.org); NIA, National Institute on Aging (http://www.ncrad.org); NIMH, National Institute of Mental Health¹²; SNP, single-nucleotide polymorphism.

^aAll P values are 1-tailed.

^bCombined probability test by Fisher.¹⁵

^cTransmission of minor allele is opposite to that in the original publication; P value is expressed as 1 − P.

^dCalculated based on the FBAT-LOGRANK statistic in PBAT (http://www.biostat.harvard.edu/~clange/default.htm).