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. 2010 Feb 23;10:61. doi: 10.1186/1471-2407-10-61

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Copyright ©2010 Ferreira et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Canine mammary biopsies with flat epithelial atypia (FEA) H&E stain. 3A Low-power view; terminal duct lobular unit shows larger acini with cellular atypia, prominent apical cytoplasmic snouts, to be lined by >2 cell layers. 200×; 3B Higher power view; the columnar epithelial cells (> 2 layers) lining the acini with intraluminal secretions show cytological atypia, characterized by apical cytoplasmic snouts and enlarged, uniform nuclei; the nuclear/cytoplasmic ratio is increased. Nucleoli are evident in some of the nuclei, 600×.