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Model for S-phase checkpoint regulation of Dia2 ubiquitin-mediated destruction. In response to replication stress, replication forks stall and activate S-phase checkpoint pathways, leading to the inhibition of Dia2 protein turnover. Our data suggest that Dia2 stabilization is downstream of both Rad53 and Chk1 activation and work from other groups indicate that Dia2 binds to Mrc1 [31,32].
