Table 1.
Statistical analysis of erythema and oedema scores*.
| Assay | Time (h) | ANOVA | Post Test Results |
|---|---|---|---|
| Erythema | 0 | p < 0.0001 | Negative control < Positive Control (p < 0.001) |
| Negative control < pH 4 (p < 0.001) | |||
| Negative control < pH 5.6 (p < 0.001) | |||
| Negative control < pH 7 (p < 0.001) | |||
| Negative control < pH 9 (p < 0.001) | |||
| Erythema | 24 | p = 0.0018 | Negative control < Positive Control (p < 0.01) |
| Negative control < pH 4 (p < 0.05) | |||
| Negative control < pH 5.6 (p < 0.01) | |||
| Negative control < pH 7 (p < 0.05) | |||
| Erythema | 48 | p < 0.0001 | Negative control < Positive Control (p < 0.001) |
| Negative control < pH 4 (p < 0.001) | |||
| Negative control < pH 5.6 (p < 0.001) | |||
| Negative control < pH 7 (p < 0.001) | |||
| Negative control < pH 9 (p < 0.001) | |||
| pH 9 < Positive Control (p < 0.01) | |||
| pH 9 < pH 4 (p < 0.05) | |||
| pH 9 < pH 5.6 (p < 0.01) | |||
| Erythema | 72 | p < 0.0001 | Negative control < Positive Control (p < 0.001) |
| Negative control < pH 4 (p < 0.001) | |||
| Negative control < pH 5.6 (p < 0.001) | |||
| Negative control < pH 7 (p < 0.001) | |||
| pH 9 < Positive Control (p < 0.01) | |||
| pH 9 < pH 4 (p < 0.05) | |||
| pH 9 < pH 5.6 (p < 0.05) | |||
| Oedema | 0 | p < 0.0001 | Negative control < Positive Control (p < 0.001) |
| Negative control < pH 4 (p < 0.001) | |||
| Negative control < pH 5.6 (p < 0.001) | |||
| Negative control < pH 7 (p < 0.001) | |||
| Negative control < pH 9 (p < 0.001) | |||
| Oedema | 24 | p = 0.0007 | Negative control < Positive Control (p < 0.01) |
| Negative control < pH 4 (p < 0.01) | |||
| Negative control < pH 5.6 (p < 0.001) | |||
| Negative control < pH 7 (p < 0.01) | |||
| Negative control < pH 9 (p < 0.01) | |||
| Oedema | 48 | p < 0.0001 | Negative control < Positive Control (p < 0.001) |
| Negative control < pH 4 (p < 0.001) | |||
| Negative control < pH 5.6 (p < 0.001) | |||
| Negative control < pH 7 (p < 0.001) | |||
| Negative control < pH 9 (p < 0.001) | |||
| pH 4 < Positive Control (p < 0.05) | |||
| pH 7 < Positive Control (p < 0.01) | |||
| pH 9 < Positive Control (p < 0.001) | |||
| pH 4 < pH 5.6 (p < 0.05) | |||
| pH 7 < pH 5.6 (p < 0.01) | |||
| pH 9 < pH 5.6 (p < 0.001) | |||
| Oedema | 72 | p = 0.0001 | Negative control < Positive Control (p < 0.001) |
| Negative control < pH 4 (p < 0.001) | |||
| Negative control < pH 5.6 (p < 0.01) | |||
| Negative control < pH 7 (p < 0.05) | |||
| pH 9 < Positive Control (p < 0.01) | |||
| pH 9 < pH 4 (p < 0.05) |
*Statistical analyses were performed using one-way ANOVAs with Tukey-Kramer Multiple Comparisons Post Tests. All treatment groups were compared in an ANOVA, and if the ANOVA indicated significant differences were present between groups, each treatment group was compared to every other treatment group in post testing. Only statistically significant post test results are shown. Any treatment group comparisons not listed were not significantly different from one another (p > 0.05).