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. 2010 Feb 17;10:46. doi: 10.1186/1471-2148-10-46

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Copyright ©2010 Stich et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dynamics of a population subjected to regular bottlenecks. The frequency of application of extreme population bottlenecks, where a single molecule has to regenerate the whole population, threatens the long-term survivability of the ensemble. We show three representative simulations corresponding to (a) 40; (b) 25; and (c) 10 generations between consecutive bottlenecks. Open symbols in black represent the total number of sequences in the population; red curves stand for the total number of correctly folded sequences. Note the variable number of generations required for saturation of the population size in plots (a) and (b).