. Author manuscript; available in PMC: 2011 Mar 24.

Published in final edited form as: J Am Chem Soc. 2010 Mar 24;132(11):3965–3972. doi: 10.1021/ja910900p

Table 4.

Alkylation of C-H Bonds^a


entry	amide	AlkI(Br)	major product	yield, %
1		i-Butyl iodide		58
2		n-Octyl iodide		47
3		n-Propyl iodide		77
4				45
5		benzyl bromide		64

Amide (1 equiv), Pd(OAc)₂ (0.05 equiv), base (2.5-3.5 equiv), pivalic acid (0.2 equiv), and RI or RBr (3-4 equiv) Yields are isolated yields. See the Supporting Information for details.