Table 1.
Microorganisms | Parameters | Test substances | |||||
---|---|---|---|---|---|---|---|
CH2Cl2 extract | A | B | C | Gentamicin | Nystatin | ||
Bacteria | |||||||
Salmonella typhi | MIC | 312.50 | na | na | na | 50 | / |
MBC | 625 | / | / | / | 50 | ||
MBC/MIC | 2 | / | / | / | 1 | ||
Staphylococcus aureus | MIC | 625 | 6.25 | na | 6.25 | 50 | / |
MBC | 625 | 12.50 | / | 12.50 | 50 | ||
MBC/MIC | 1 | 2 | / | 2 | 1 | ||
Enterococcus faecalis | MIC | 1250 | 3.12 | na | 1.56 | 12.50 | / |
MBC | 1250 | 6.25 | / | 1.56 | 12.50 | ||
MBC/MIC | 1 | 2 | / | 1 | 1 | ||
Proteus mirabilis | MIC | 625 | 25 | na | 50 | 100 | / |
MBC | 1250 | 50 | / | 50 | 100 | ||
MBC/MIC | 2 | 2 | / | 1 | 1 | ||
Yeasts | |||||||
Candida albicans | MIC | 1250 | 100 | na | 50 | / | 1.56 |
MFC | 1250 | 100 | / | 50 | 1.56 | ||
MFC/MIC | 1 | 1 | / | 1 | 1 | ||
Candida parapsilosis | MIC | 625 | 50 | 400 | 25 | / | 12.50 |
MFC | 625 | 100 | 400 | 50 | 12.50 | ||
MFC/MIC | 1 | 2 | 1 | 2 | 1 | ||
Candida tropicalis | MIC | 312.50 | 12.50 | 200 | 6.25 | / | 6.25 |
MFC | 625 | 50 | 200 | 12.50 | 6.25 | ||
MFC/MIC | 2 | 4 | 1 | 2 | 1 |
/: Not tested; A: 6β-(2-methylbut-2(Z)-enoyl)-3α,4α,15,16-bis-epoxy-8β,10βH-ent-cleroda-13(16),14-dien-20,12-olide; B: 10β-hydroxy-6-oxo - 3α,4α,15,16-bis-epoxy-8βH-cleroda-13(16),14-dien-20,12-olide; C: Spinasterol; na: Not active at concentrations up to 400 μg/ml