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. 2009 Apr;41(2):60–63. doi: 10.4103/0253-7613.51340

Table 1.

Inhibition parameters (MIC, MBC and MFC) of methylene chloride extract of M. angolensis and some of its isolated constituents (μg/ml)

Microorganisms Parameters Test substances

CH2Cl2 extract A B C Gentamicin Nystatin
Bacteria
Salmonella typhi MIC 312.50 na na na 50 /
MBC 625 / / / 50
MBC/MIC 2 / / / 1
Staphylococcus aureus MIC 625 6.25 na 6.25 50 /
MBC 625 12.50 / 12.50 50
MBC/MIC 1 2 / 2 1
Enterococcus faecalis MIC 1250 3.12 na 1.56 12.50 /
MBC 1250 6.25 / 1.56 12.50
MBC/MIC 1 2 / 1 1
Proteus mirabilis MIC 625 25 na 50 100 /
MBC 1250 50 / 50 100
MBC/MIC 2 2 / 1 1
Yeasts
Candida albicans MIC 1250 100 na 50 / 1.56
MFC 1250 100 / 50 1.56
MFC/MIC 1 1 / 1 1
Candida parapsilosis MIC 625 50 400 25 / 12.50
MFC 625 100 400 50 12.50
MFC/MIC 1 2 1 2 1
Candida tropicalis MIC 312.50 12.50 200 6.25 / 6.25
MFC 625 50 200 12.50 6.25
MFC/MIC 2 4 1 2 1

/: Not tested; A: 6β-(2-methylbut-2(Z)-enoyl)-3α,4α,15,16-bis-epoxy-8β,10βH-ent-cleroda-13(16),14-dien-20,12-olide; B: 10β-hydroxy-6-oxo - 3α,4α,15,16-bis-epoxy-8βH-cleroda-13(16),14-dien-20,12-olide; C: Spinasterol; na: Not active at concentrations up to 400 μg/ml