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. 2010 Mar 9;2010:525180. doi: 10.1155/2010/525180

Figure 3.

Figure 3

Lack of involvement of cGMP and PKC in P-gp regulation. ((a) n = 3–6) P-gp transport activity in GERP cells after exposure to 10 ng/mL TNF-α in combination with 10 μM of the sGC inhibitor ODQ for 24 hours compared to control (cells exposed to culture medium). ((b) n = 3) P-gp transport activity in GERP cells after exposure to 10 ng/mL TNF-α in combination with 100 nM of the PKC inhibitor BIM for 24 hours compared to control. Data are expressed as mean ± SEM. Significantly different compared to control (*: P < .05; ***: P < .001). Treatment with ODQ or BIM alone showed no significant difference compared to control.