Table 1.
Amino acid sequences of tryptophan and/or lysine-flanked transmembrane model peptides used in literature
| Model peptide | Amino acid sequence | References |
|---|---|---|
| Peptides flanked by tryptophans | ||
| WALPx, x = 2m + n + 6 | Ac-GWW(LA)mLnWWA-amidea, m = {3, 5, 6, 7, 8, 10, 12}, n = {0, 1} | Killian et al. (1996), de Planque et al. (1998, 1999, 2001, 2003), Demmers et al. (2001), Rinia et al. (2002), Strandberg et al. (2002), Petrache et al. (2002), Morein et al. (2002), van der Wel et al. (2002, 2007); Kol et al. (2003), Weiss et al. (2003), Andronesi et al. (2004), Ganchev et al. (2004), Strandberg et al. (2004), van Duyl et al. (2005), Özdirekcan et al. (2005, 2007), Im and Brooks (2005), Sparr et al. (2005a, b), Siegel et al. (2006), Holt et al. (2008) |
| GWALP23 | Ac-GGALW(LA)6LWLAGA-ethanolamine | Vostrikov et al. (2008) |
| WLP23 | Ac-GWWL17WWA-amide | Özdirekcan et al. (2005), Esteban-Martin and Salgado (2007a) |
| WL22 | Ac-WWL18WW-amide | Esteban-Martin and Salgado (2007b) |
| WA22 | Ac-WWA18WW-amide | Esteban-Martin and Salgado (2007b) |
| Peptides flanked by tryptophans and lysines | ||
| LW | Ac-KKWWL8AL8WWKK-amide | Fastenberg et al. (2003) |
| W-L22-W | Ac-KKWL22WKK-amide | Liu et al. (2002) |
| KWALP23 | Ac-GKALW(LA)6LWLAKA-amide | Daily et al. (2008) |
| Peptides flanked by lysines | ||
| KALPx, x = 2m + 7 | Ac-GKK(LA)mLWWA-amide, m = {6, 8, 10, 12} | de Planque et al. (2001), Strandberg et al. (2002), Morein et al. (2002), Kol et al. (2003), van Duyl et al. (2005), Özdirekcan et al. (2005), Kandasamy and Larson (2006) |
| (LA)12 | Ac-KK(LA)12KK-amide | Zhang et al. (1995a, b, 2001) |
| KLP23 | Ac-GKKL17KKA-amide | Özdirekcan et al. (2005), Esteban-Martin and Salgado (2007a) |
| L24 | Ac-KKL24KK-amide | Axelsen et al. (1995), Subczynski et al. (1998), Liu et al. (2002) |
| P16/24 | Ac-KKGL16/24KKA-amide | Davis et al. (1983), Huschilt et al. (1985), Morrow et al. (1985), Huschilt et al. (1989), Zhang et al. (1992a, b, 1995c) |
| A24 | Ac-KKA24KK-amide | Lewis et al. (2001) |
| Peptides flanked by lysines that include a tryptophan in the hydrophobic stretch | ||
| p(LA)6/8 | Ac-KKG(LA)3/4W(LA)3/4KKA-amide | Vidal and McIntosh (2005), Krishnakumar and London (2007) |
| pLx, x = 2m | Ac-KKGLmWLmKKA-amide, m = {5, 6, 7, 8, 9, 10, 11} | Ren et al. (1999), Caputo and London (2003), Lew et al. (2003), Krishnakumar and London (2007), Shahidullah and London (2008) |
| pLmAm, m = {6, 7, 8} | Ac-KKGLmWAmKKA-amide | Krishnakumar and London (2007) |
| pA18/22 | Ac-KKA9/11WA9/11KK-amide | Shahidullah and London (2008) |
aIn some cases ethanolamine is used instead