Skip to main content
. Author manuscript; available in PMC: 2011 Mar 15.
Published in final edited form as: Bioorg Med Chem. 2010 Feb 4;18(6):2265–2274. doi: 10.1016/j.bmc.2010.01.063

Table 1.

Inhibition of AChE by Cyclic Phosphonatesa

Compound Structure IC50, uM Ki, uMb k2, min−1b k−2, min−1b
1 graphic file with name nihms177576t1.jpg 8e-4c n/a n/a n/a
2a graphic file with name nihms177576t2.jpg 3d 24 ± 6.0 0.3 ± 0.06 0.02
2b graphic file with name nihms177576t3.jpg 30d 140 ± 58 0.4 ± 0.1 4e-3
3a graphic file with name nihms177576t4.jpg ≈ 35 n/a n/a n/a
3b graphic file with name nihms177576t5.jpg ≈ 6 n/a n/a n/a
9 graphic file with name nihms177576t6.jpg 7 76 ± 20 0.2 ± 0.03 0.01
10 graphic file with name nihms177576t7.jpg 600 n/a n/a n/a
15 graphic file with name nihms177576t8.jpg 5 310 ± 130 4.2 ± 1.5 0.13
17a graphic file with name nihms177576t9.jpg >1000 n/a n/a n/a
17b graphic file with name nihms177576t10.jpg 70 n/a n/a n/a
DIFP graphic file with name nihms177576t11.jpg 0.12 6.0±1.0 1.0 ± 0.1 0.13
a

All values are against the human enzyme unless otherwise specified.

b

Data analyzed according to Eqn 1.

c

Value is against insect enzyme.8

d

Ref.9.