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. Author manuscript; available in PMC: 2010 Mar 18.
Published in final edited form as: Nat Genet. 2005 Jun 19;37(7):710–717. doi: 10.1038/ng1589

Figure 4.

Figure 4

Three genes in the OFPM causality list achieve validation in genetically modified mice. (a,b) Growth curves for C3ar1−/− (a) and Tgfbr2+/− (b; mutant) and control mice over seven time points. Growth is given on the y axis as the fat mass to lean mass ratio. At each time point the mean ratio is plotted for each group. The significance of the mean ratio differences at time point 7 is given in Table 3. (c) Genetic subnetwork for liver expression in the BXD cross previously described13 highlights Zfp90 (black node) as a central node in the liver transcriptional network of this cross. This subnetwork was obtained from the full liver expression network previously described13 by identifying all nodes in this network that were descended from and within a path length of 3 of the Zfp90 node. Nodes highlighted in green represent genes testing as causal for fat mass (Supplementary Table 2 online).