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. Author manuscript; available in PMC: 2010 Mar 18.
Published in final edited form as: J Med Chem. 2008 Dec 25;51(24):8048–8056. doi: 10.1021/jm801162z

Scheme 1a.

Scheme 1a

a Reagents: (a) ArMgBr, Et2O, −45 °C, 2 h, then −78 °C; (b) TFA; (c) 1.1 eq. Br2, 2.0 eq. SnCl4, 0 °C, 30 min for 7d; (d) 2.2 eq. Br2, 4.0 eq. SnCl4, room temperature, 3 h for 7e; (e) ICl, AcOH, room temperature, 24 h for 7f; (f) I(Py)2BF4, CF3SO3H, dioxane, room temperature, 3 h for 7g.