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. 2010 Mar 12;4:6. doi: 10.3389/neuro.08.006.2010

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Copyright © 2010 Cunha, Monfils and LeDoux.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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In vitro patch clamp recordings, showed functional GABA_CRs in the rat LA. (A) Recorded traces of a pyramidal cell in the LA during control, application of 1 μM muscimol (GABA_CR agonist), addition of 50 μM CGP 52432 (GABA_BR antagonist), and co-application of 10 μM bicuculline (GABA_AR antagonist). (B) Average effect of 1 μM muscimol on synaptic currents of pyramidal cells in the LA compared to Control (n = 23). (C) Traces of synaptic currents of a pyramidal cell in the LA under control conditions, application of 30 μM TPMPA (GABA_CR agonist), 50 μM CGP 52432 (GABA_BR antagonist), and addition of bicuculline to CGP 52432. (D) Effect of 30 μM TPMPA on all recorded pyramidal cells in the LA compared to control (n = 14).