Expression of sesBs exclusively in tubule principal cells modulates survival of the whole fly under oxidative stress. A, B: survival of flies after ingestion of H2O2. A: survival of flies in which sesB-1 and sesB-2 were targeted to tubule principal cells. B: survival of flies in which sesB RNAi was targeted to tubule principal cells and from male viable hypomorphic allele of sesB1. Outcrossed parental lines are shown in gray (UAS-sesB-1, UAS-sesB-2, and UAS-sesB RNAi) or black (UO-GAL4 > WhCS) and were generated to control for genetic background of the sesB transgenics stocks. Data are expressed as numbers of surviving flies up to 150 h ± SE, n > 30 flies per vial, repeated 3 times for each genotype.