Fig. 3.

Values for cholesterol, triglycerides, glucagon, insulin, and leptin in serum of female and male DR.^+/+, DR.^{lepr−/lepr−}, and DR.^{lepr−/lepr−,Gimap5−/Gimap5−} rats. Serum samples were evaluated at 180 days of age for the +/+ (open bars) and lepr−/lepr− (hatched bars) rats and at 150 days of age for lepr−/lepr−,Gimap5−/Gimap5− (filled bars) double congenic animals. Bars that share common symbols in the same chart are significantly different (P < 0.05) (Student's t-test). Leptin levels in DR.^{lepr−/lepr−,Gimap5−/Gimap5−}: female > male (P = 0.051). Data are means ± SE (n = 3–5/group).