Fig. 6.

Score assessment of pancreatic islet size (top), degeneration (middle), and inflammation (bottom). Values for female (1–4) and male (5–8) rats. Open bars, DR.^+/+ (1 and 5); hatched bars, DR.^{lepr−/lepr−} (2 and 6); checkerboard bars, DR.^{Gimap5−/Gimap5−} (3 and 7); filled bars, DR.^{lepr−/lepr−,Gimap5−/Gimap5−} (4 and 8). Ages for scores are as follows: 1, 2, 5, and 6, 180 days of age; 3 and 7, a day after diabetes onset; 4, 150 days of age; 8, between 15 and 27 days after diabetes onset. Groups marked by common symbols in the same chart are significantly different (P < 0.05). Data are means ± SE (n = 3–5/group).