Table 3.
Serum cytokines and adipokines at 180 days of age in DR.lepr−/lepr− line
| Females |
Males |
|||||
|---|---|---|---|---|---|---|
| DR.+/+ | DR.lepr−/lepr− | P value | DR.+/+ | DR.lepr−/lepr− | P value | |
| Eotaxin | 69.45 ± 25.9 | 136.3 ± 95.0 | ns | 45.55 ± 5.0 | 196.5 ± 53.1 | 0.06 |
| GRO/KC | 718.1 ± 45.5 | 2,830 ± 787.7 | 0.07 | 949.2 ± 61.1 | 1,009 ± 192.4 | ns |
| IL-13 | 1,005 ± 432.9 | 1,941 ± 1,358 | ns | 551.1 ± 113.4 | 2,174 ± 450.0 | * |
| IFN-γ | 418.0 ± 180.7 | 926.0 ± 655.9 | ns | 254.5 ± 59.1 | 1,103 ± 261.8 | * |
| RANTES | 9,245 ± 359.9 | 13,470 ± 1,513 | 0.06 | 15,450 ± 2,244 | 10,050 ± 2,020 | ns |
| MCP-1 | 173.3 ± 30.7 | 720.9 ± 75.8 | † | 337.6 ± 44.6 | 296.4 ± 39.3 | ns |
Data (in pg/ml) represent means ± SE for n = 4 rats/group for each genotype in male and female rats. RANTES, regulated on activation, normal T expressed and secreted; MCP-1, monocyte chemoattractant protein-1. Significance values of the means were determined by Student's t-test.
*
P < 0.05,
†
P < 0.001.