Table 3.

Proportion of Participants and Odds of Having a 10-Year Framingham Risk Score for CHD Death or Myocardial Infarction >20% by Metabolic Syndrome Classification in those Free of CHD^* in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.

	Number free of Baseline CHD	FRS >20%
		N	%	OR (95% CI)§
All Participants
Using Diabetes as a CAD Risk Factor †
No MetSyn	9,665	571	6	Referent
MetSyn by IDF-Only	1,163	151	13	2.29 (1.81, 2.88)
MetSyn by Both	6,347	1,301	21	7.34 (6.39, 8.44)
MetSyn by ATP-Only	495	167	34	7.48 (5.75, 9.73)
Using Diabetes as a CAD Risk Equivalent ‡
No MetSyn	9,665	918	9	Referent
MetSyn by IDF-Only	1,163	326	28	4.64 (3.84, 5.59)
MetSyn by Both	6,347	2,868	45	15.37 (13.66, 17.30)
MetSyn by ATP-Only	495	224	45	11.58 (8.74, 15.34)
Non-Diabetic Participants
No MeSyn	9,240	493	5	Referent
MetSyn by IDF-Only	935	98	10	2.17 (1.63, 2.89)
MetSyn by Both	3,976	497	13	4.79 (4.01, 5.72)
MetSyn by ATP-Only	358	87	24	5.40 (3.83, 7.62)

ATP, Adult Treatment Panel; CAD, Coronary Artery Disease; CHD, Coronary Heart Disease; CI, Confidence Interval; FRS, Framingham Risk Score; IDF, International Diabetes Federation; MetSyn, Metabolic Syndrome; OR, Odds Ratio.

^*Individuals were considered to be free of CHD if they did not have a self-reported history of CHD (myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft surgery) or evidence of myocardial infarction on their enrollment electrocardiogram.

^†For this analysis, we calculated 10-Year Framingham Risk Scores for CHD death or myocardial infarction using diabetes as a risk factor for CAD as published by Wilson et al.³²

^‡For this analysis, we considered diabetes to be a CAD risk equivalent as recommended by ATP III⁴, and assumed that all diabetics had a 10-Year Framingham Risk for CHD death or myocardial infarction of >20%.

^§Adjusted for age, gender, race, geography, education, income, smoking status, alcohol use, and physical activity.