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A model for serous carcinogenesis in the distal fallopian tube, genotoxic stress imposed on the secretory cells (ovals) produces a p53 mutation followed by LOH of the non-mutated allele, with accumulation of p53 protein. Capacity of the affected cell for expansion is variable. Functional loss of BRCA1/2 via one or more mechanisms is a necessary component of progression to malignancy and is increased in women with inherited heterozygous BRCA1/2 mutations.
