Figure 3.

Serum PTH, 1,25(OH)₂D, and urinary calcium excretion in the four groups. Error bars and group symbols are as in Fig. 1. A, Endogenous PTH (1-84) declined in all three PTHrP groups (P < 0.01 vs. placebo). To convert picograms per milliliter to picomoles, divide by 10. B, 1,25(OH)₂D increased in each PTHrP group during the study (P < 0.03 over time). To convert to picomoles per liter, multiply by 2.6. C, Fasting fractional calcium excretion. Whereas the four groups began the study with different values, reflecting the small numbers of subjects, there was no significant change over time in any of the four groups during the study. D, Twenty-four-hour calcium excretion on d 0 and d 21 of the study. Note that whereas fasting fractional calcium excretion did not increase with treatment (C), 24-h urine calcium excretion did tend to increase during the study, although these changes achieved statistical significance only in the 625 μg/d group (P < 0.0001 over time, P < 0.05 vs. placebo). Also note that only 10 of 15 placebo subjects and five of 10 subjects in the 500 μg/d and placebo groups had these measurements because they were added to the protocol after the initial 10 subjects were enrolled.