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Binding and cell activation by fMLF-PEG bioconjugate-based nanocarriers [99]
| Competitor | Avidity: Kd (nM) | Cell activation: EC50 (nM) | Relative avidity: Kd × no. of fMLF | Avidity/activation: EC50/Kd |
|---|---|---|---|---|
| fMLF | 28 | 4.7 | 28 | 0.168 |
| B8-PEG-fMLF1.1 | 190 | - | 209 | - |
| B3-PEG-fMLF3 | 1.9 | 9.6 | 5.7 | 5.05 |
| B4-PEG-fMLF4 | 0.8 | 5.0 | 3.2 | 6.25 |
| B8-PEG-fMLF5.5 | 0.5 | 5.3 | 2.75 | 10.6 |
| B8-PEG-fMLF8 | 0.18 | 5.0 | 1.44 | 27.8 |
| PEG-aspartate-fMLF4 | 1.1 | - | 4.4 | - |
| PEG-aspartate-fMLF4-DIG4 | 1.2 | 5.9 | 4.8 | 4.92 |
