Table 4.
Lutein and Age Related Macular Degeneration (ARMD), With Dietary Intake Assessed by 6 24 HR's: Standardized Relative Risks (RR*), Statistical Power and Relative Sample Size** (rss) Required for Various Analysis Strategies Under Different Disease Risk Models
| Analysis Strategy |
Disease Risk Model | |||
|---|---|---|---|---|
| (a) Not mediated through marker |
(b) Mediated entirely through marker |
(c) Partially mediated through marker |
||
|
RDIa (univariate) |
RR Power (rss) |
0.43 0.890 (1.00) |
0.55 0.629 (1.00) |
0.49 0.810 (1.00) |
|
MBLb (univariate) |
RR Power (rss) |
0.47 0.829 (1.20) |
0.32 0.995 (0.25) |
0.38 0.972 (0.54) |
| Bivariatec | RR RDI RR MBL Power (rss) |
0.53 0.61 0.904 (0.95) |
0.87 0.33 0.986 (0.30) |
0.67 0.44 0.968 (0.55) |
| Howed (ranks) | RR Power (rss) |
0.38 0.959 (0.74) |
0.34 0.985 (0.31) |
0.35 0.974 (0.53) |
| Principal Componentse | RR Power (rss) |
0.39 0.952 (0.77) |
0.35 0.984 (0.31) |
0.37 0.977 (0.51) |
* Standardized relative risk is defined as the RR between the 90th and 10th percentiles of the distribution.
Bold type indicates the most powerful method among the available choices investigated.
** Sample size requirement relative to the univariate RDI analysis.
a Regression of ARMD on RDI
b Regression of ARMD on MBL
c Regression of ARMD on RDI and MBL
d Regression of ARMD on combination of RDI and MBL using Howe's method
e Regression of ARMD on combination of RDI and MBL using Principal Components