Table 2. Selected genes/operons co-regulated by CcpA and CovR under laboratory conditions.
| Gene category | M5005 spy number | Gene name | Function of encoded protein(s) | 2221ΔccpA | 2221ΔcovR | 2221ΔcovRΔccpA |
| Virulence factors | ||||||
| 0139 | nga | NAD glycohydrolase | 3.6a | 12.1 | 31.2 | |
| 0141 | slo | Pore forming cytoxin | 2.7 | 12.3 | 25.3 | |
| 0341 | spyCEP | IL-8 degrading protease | 8.3 | 17.3 | 25.5 | |
| 0562 | sagA | Secreted cytotoxin | 2.7 | 2.3 | 8.4 | |
| 1415 | sdaD2 | DNase | 2.3 | 2.7 | 2.2 | |
| 1540 | endoS | Immunoglobulin modifying protein | 21.3 | 2.6 | 26.6 | |
| 1714 | fba | Fibronectin-binding protein | 3.2 | 4.1 | 5.0 | |
| 1735 | speB | Secreted cysteine protease | −5.2 | 2.2 | −5.2 | |
| Carbohydrate utilization | ||||||
| 0212-8b | Sialic acid production and catabolism | 13.7 | 4.8 | 37.0 | ||
| 1079-83 | Cellobiose transport | 8.4 | 3.1 | 12.7 | ||
| 1062-7 | Cyclodextrin transport and catabolism | 7.9 | 2.4 | 8.8 | ||
| 1538-43 | Sucrose transport and catabolism | 13.3 | 2.3 | 19.0 | ||
| 1632-8 | Lactose transport and catabolism | 6.32 | 2.9 | 11.3 | ||
| Amino acid utilization | ||||||
| 1271-5 | Arginine catabolism | 22.0 | 2.7 | 29.4 | ||
| 1770-8 | Histidine catabolism | 5.73 | 2.3 | 11.3 |
a
Numbers show mean-fold-change in transcript level between wild-type (strain MGAS2221) and indicated isogenic mutant strain with positive numbers indicating higher transcript level in isogenic mutant strain compared to wild-type.
b
Numbers listed for carbohydrate and amino acid utilization operons indicate mean-fold-change in transcript level for all genes in the indicated operon for isogenic mutant strain compared to wild-type.