|
number of trimers on virion |
|
probability that virion has trimers |
|
fraction of dominant negative Env-mutant encoding plasmids |
|
fraction of antibody-resistant Env-mutant encoding plasmids |
|
probability of forming a “functional” trimer in the entry assay,
|
|
probability of forming a “functional” spike in the neutralization assay, see equation (1) |
|
number of “functional” trimer on virion |
|
number of trimer-receptor interactions needed for entry |
|
number of antibodies-Env interactions required to neutralize one spike |
|
variance coefficient (imperfect transfection model) |
|
segregation coefficient ranging from 0 (no segregation) to 1 (full segregation) |
|
maximal distance of trimers required for cooperation in an infective cluster |
|
Number of trimers for which infectivity is 1/2 |
|
softness parameter (Hill coeficient) in the soft threshold model |